Cis-regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancers.

ABSTRACT: Human papillomavirus (HPV) infections are the primary drivers of cervical cancers, and often HPV DNA gets integrated into the host genome. Although the oncogenic impact of HPV encoded genes is relatively well known, the cis-regulatory effect of integrated HPV DNA on host chromatin structure and gene regulation remains less understood. We investigated genome-wide patterns of HPV integrations and associated host gene expression changes in the context of host chromatin states and topologically associating domains (TADs). HPV integrations were significantly enriched in active chromatin regions and depleted in inactive ones. Interestingly, regardless of chromatin state, genomic regions flanking HPV integrations showed transcriptional upregulation. Nevertheless, upregulation (both local and long

SUBMITTER: Singh AK 

PROVIDER: S-EPMC11076994 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature