Investigating shared genetic architecture between inflammatory bowel diseases and primary biliary cholangitis.

ABSTRACT:

Background & aims

Inflammatory bowel disease (IBD) is commonly associated with extraintestinal complications, including autoimmune liver disease. The co-occurrence of IBD and primary biliary cholangitis (PBC) has been increasingly observed, but the underlying relationship between these conditions remains unclear.

Methods

Using summary statistics from genome-wide association studies (GWAS), we investigated the causal effects between PBC and IBD, including Crohn's disease (CD) and ulcerative colitis (UC). We also analyzed the shared genetic architecture between IBD and PBC using data from GWAS, bulk-tissue RNA sequencing, and single cell RNA sequencing, and explored potential functional genes.

Result

There was a strong positive genetic correlation between PBC and IBD (l

SUBMITTER: Huang W 

PROVIDER: S-EPMC11077043 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature