Re-examining Correlations Between Synonymous Codon Usage and Protein Bond Angles in Escherichia coli.

ABSTRACT: Rosenberg AA, Marx A, Bronstein AM (Codon-specific Ramachandran plots show amino acid backbone conformation depends on identity of the translated codon. Nat Commun. 2022:13:2815) recently found a surprising correlation between synonymous codon usage and the dihedral bond angles of the resulting amino acid. However, their analysis did not account for the strongest known correlate of codon usage: gene expression. We re-examined the relationship between bond angles and codon usage by applying the approach of Rosenberg et al. to simulated protein-coding sequences that (i) have random codon usage, (ii) codon usage determined by mutation biases, and (iii) maintain the general relationship between codon usage and gene expression via the assumption of selection-mutation-drift equilibrium. We obser

SUBMITTER: Akeju OJ 

PROVIDER: S-EPMC11077309 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature