Causal relationship between dyslipidemia and risk of facial aging: Insights from Mendelian randomization in East Asian populations.

ABSTRACT:

Background

Emerging observational studies showed an association between dyslipidemia and aging. However, it remains unclear whether this association is causal, particularly in the case of Asians, which are aging more rapidly than other continents. Given the visible manifestations of aging often include changes in facial appearance, the objective of this study is to assess the causal relationship between dyslipidemia and facial aging in East Asian populations.

Methods

SNPs related to dyslipidemia in East Asian people such as Total cholesterol (TC), High-density-lipoprotein cholesterol (HDL), Low-density-lipoprotein cholesterol (LDL), and Triglyceride (TG) along with outcomes data on facial aging, were extracted from public genome-wide association studies (GWAS). A two-sample

SUBMITTER: Deng Y 

PROVIDER: S-EPMC11077566 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature