Proteomics Defines Plasma Biomarkers for the Early Diagnosis of Biliary Atresia.

ABSTRACT: Early diagnosis of biliary atresia (BA) is crucial for improving the chances of survival and preserving the liver function of pediatric patients with BA. Herein, we performed proteomics analysis using data-independent acquisition (DIA) and parallel reaction monitoring (PRM) to explore potential biomarkers for the early diagnosis of BA compared to other non-BA jaundice cases. Consequently, we detected and validated differential protein expression in the plasma of patients with BA compared to the plasma of patients with intrahepatic cholestasis. Bioinformatics analysis revealed the enriched biological processes characteristic of BA by identifying the differential expression of specific proteins. Signaling pathway analysis revealed changes in the expression levels of proteins associated with

SUBMITTER: Fu M 

PROVIDER: S-EPMC11077583 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature