Mucosal-associated invariant T cells promote ductular reaction through amphiregulin in biliary atresia.

ABSTRACT:

Background

Biliary atresia (BA) is a neonatal fibro-inflammatory cholangiopathy with ductular reaction as a key pathogenic feature predicting poor survival. Mucosal-associated invariant T (MAIT) cells are enriched in human liver and display multiple roles in liver diseases. We aimed to investigate the function of MAIT cells in BA.

Methods

First, we analyzed correlations between liver MAIT cell and clinical parameters (survival, alanine transaminase, bilirubin, histological inflammation and fibrosis) in two public cohorts of patients with BA (US and China). Kaplan-Meier survival analysis and spearman correlation analysis were employed for survival data and other clinical parameters, respectively. Next, we obtained liver samples or peripheral blood from BA and control patients

SUBMITTER: Xiao MH 

PROVIDER: S-EPMC11077624 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature