Response mechanisms of different Saccharomyces cerevisiae strains to succinic acid.

ABSTRACT:

Background

The production of succinic acid (SA) from biomass has attracted worldwide interest. Saccharomyces cerevisiae is preferred for SA production due to its strong tolerance to low pH conditions, ease of genetic manipulation, and extensive application in industrial processes. However, when compared with bacterial producers, the SA titers and productivities achieved by engineered S. cerevisiae strains were relatively low. To develop efficient SA-producing strains, it's necessary to clearly understand how S. cerevisiae cells respond to SA.

Results

In this study, we cultivated five S. cerevisiae strains with different genetic backgrounds under different concentrations of SA. Among them, KF7 and NBRC1958 demonstrated high tolerance to SA, whereas NBRC2018 displayed the leas

SUBMITTER: Xie CY 

PROVIDER: S-EPMC11077785 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature