Tear Proteomics in Infants at Risk of Retinopathy of Prematurity: A Feasibility Study.

ABSTRACT:

Purpose

This feasibility study investigated the practicability of collecting and analyzing tear proteins from preterm infants at risk of retinopathy of prematurity (ROP). We sought to identify any tear proteins which might be implicated in the pathophysiology of ROP as well as prognostic markers.

Methods

Schirmer's test was used to obtain tear samples from premature babies, scheduled for ROP screening, after parental informed consent. Mass spectrometry was used for proteomic analysis.

Results

Samples were collected from 12 infants, which were all adequate for protein analysis. Gestational age ranged from 25 + 6 to 31 + 1 weeks. Postnatal age at sampling ranged from 19 to 66 days. One infant developed self-limiting ROP. Seven hundred one proteins were identified; 261 p

SUBMITTER: Shipton C 

PROVIDER: S-EPMC11077915 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature