Autoimmune Movement Disorders Complicating Treatment with Immune Checkpoint Inhibitors.

ABSTRACT:

Background

Immune checkpoint inhibitors (ICI) may trigger autoimmune neurological conditions, including movement disorders (MD).

Objectives

The aim of this study was to characterize MDs occurring as immune-related adverse events (irAEs) of ICIs.

Methods

A systematic literature review of case reports/series of MDs as irAEs of ICIs was performed.

Results

Of 5682 eligible papers, 26 articles with 28 patients were included. MDs occur as a rare complication of cancer immunotherapy with heterogeneous clinical presentations and in most cases in association with other irAEs. Inflammatory basal ganglia T2/fluid attenuated inversion recovery abnormalities are rarely observed, but brain imaging is frequently unrevealing. Cerebrospinal fluid findings are frequently suggest

SUBMITTER: Dinoto A 

PROVIDER: S-EPMC11078485 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature