Fatigue Impacts Quality of Life in People with Spinocerebellar Ataxias.

ABSTRACT:

Background

Fatigue is a prevalent and debilitating symptom in neurological disorders, including spinocerebellar ataxias (SCAs). However, the risk factors of fatigue in the SCAs as well as its impact have not been well investigated.

Objectives

To study the prevalence of fatigue in SCAs, the factors contributing to fatigue, and the influence of fatigue on quality of life.

Methods

Fatigue was assessed in 418 participants with SCA1, SCA2, SCA3, and SCA6 from the Clinical Research Consortium for the Study of Cerebellar Ataxia using the Fatigue Severity Scale. We conducted multi-variable linear regression models to examine the factors contributing to fatigue as well as the association between fatigue and quality of life.

Results

Fatigue was most prevalent in SCA3 (52

SUBMITTER: Lai RY 

PROVIDER: S-EPMC11078491 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature