Motor and Non-motor Outcomes of Deep Brain Stimulation across the Genetic Panorama of Parkinson's Disease: A Multi-Scale Meta-Analysis.

ABSTRACT:

Background

In the era of modern medicine, where high-throughput sequencing techniques are readily available, it is desirable to elucidate the role of genetic background in patients with Parkinson's Disease (PD) undergoing Deep Brain Stimulation (DBS). Genetic stratification of PD patients undergoing DBS may assist in patient selection and prediction of clinical outcomes and complement existing selection procedures such as levodopa challenge testing.

Objective

To capture a broad spectrum of motor and non-motor DBS outcomes in genetic PD patients with data from the recently updated literature.

Methods

A multi-scale meta-analysis with 380 genetic PD cases was conducted using the Cochrane Review Manager, JASP software and R.

Results

This meta-analysis revealed that

SUBMITTER: Asimakidou E 

PROVIDER: S-EPMC11078493 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature