Early megakaryocyte lineage-committed progenitors in adult mouse bone marrow.

ABSTRACT: Hematopoietic stem cells (HSCs) have been considered to progressively lose their self-renewal and differentiation potentials prior to the commitment to each blood lineage. However, recent studies have suggested that megakaryocyte progenitors (MkPs) are generated at the level of HSCs. In this study, we newly identified early megakaryocyte lineage-committed progenitors (MgPs) mainly in CD201^-CD48^- cells and CD48⁺ cells separated from the CD150⁺CD34^-Kit⁺Sca-1⁺Lin^- HSC population of the bone marrow in adult mice. Single-cell colony assay and single-cell transplantation showed that MgPs, unlike platelet-biased HSCs, had little repopulating potential in vivo, but formed larger megakaryocyte colonies in vitro

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11078525 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature