MAP7 drives EMT and cisplatin resistance in ovarian cancer via wnt/β-catenin signaling.

ABSTRACT:

Methods

Our approach encompasses analyzing MAP7's expression levels across various datasets and clinical specimens, evaluating its association with patient outcomes, and probing its influence on ovarian cancer cell dynamics such as proliferation, migration, invasion, and apoptosis.

Results

We have identified significant upregulation of MAP7 in ovarian cancer tissues, which correlates with advanced disease stages, higher pathological grades, and unfavorable prognoses. Functionally, the inhibition of MAP7 suppresses cancer cell proliferation, migration, and invasion while promoting apoptosis. Notably, the silencing of MAP7 attenuates the epithelial-mesenchymal transition (EMT) and disrupts Wnt/β-catenin pathway signaling-two critical processes implicated in metastasis and chem

SUBMITTER: Chen Q 

PROVIDER: S-EPMC11078642 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature