Rapid resistance detection is reliable for prompt adaptation of isoniazid resistant tuberculosis management.

ABSTRACT:

Objectives

Appropriate tuberculosis (TB) management requires anti-TB drugs resistance detection. We assessed the performance of rapid resistance detection assays and their impact on treatment adaptation, focusing on isoniazid resistant (Hr) TB.

Methods

From 2016 to 2022, all TB cases enrolled in 3 hospitals were reviewed for phenotypic drug susceptibility testing (p-DST) and genotypic DST (g-DST) performed by rapid molecular testing, and next generation sequencing (NGS). Clinical characteristics, treatment and outcome were collected for Hr-TB patients. The concordance between g-DST and p-DST results, and delay between treatment initiation and results of g-DST and p-DST were respectively recorded to assess the contribution of DST results on Hr-TB management.

Results

Am

SUBMITTER: Bahuaud O 

PROVIDER: S-EPMC11078763 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature