Automated synthesis of [⁸⁹Zr]ZrCl₄, [⁸⁹Zr]ZrDFOSquaramide-bisPh(PSMA) and [⁸⁹Zr]ZrDFOSquaramide-TATE.

ABSTRACT:

Background

Automated [⁸⁹Zr]Zr-radiolabeling processes have the potential to streamline the production of [⁸⁹Zr]Zr-labelled PET imaging agents. Most radiolabeling protocols use [⁸⁹Zr][Zr(ox)₄]^4- as the starting material and oxalate is removed after radiolabeling. In some instances, radiolabeling with [⁸⁹Zr]ZrCl₄ as starting material gives better radiochemical yields at lower reaction temperatures. In this work, a fully-automated process for production of [⁸⁹Zr]ZrCl₄ is reported and its use for the synthesis of [⁸⁹Zr]ZrDFOSq-bisPhPSMA and [⁸⁹Zr]ZrDFOSq-TATE.

Results

A simple automated process for the isolation of [⁸⁹Zr]ZrCl₄ by trapping

SUBMITTER: Noor A 

PROVIDER: S-EPMC11078908 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature