Identification of necroptosis-related diagnostic biomarkers in coronary heart disease.

ABSTRACT:

Background

The implication of necroptosis in cardiovascular disease was already recognized. However, the molecular mechanism of necroptosis has not been extensively studied in coronary heart disease (CHD).

Methods

The differentially expressed genes (DEGs) between CHD and control samples were acquired in the GSE20681 dataset downloaded from the GEO database. Key necroptosis-related DEGs were captured and ascertained by bioinformatics analysis techniques, including weighted gene co-expression network analysis (WGCNA) and two machine learning algorithms, while single-gene gene set enrichment analysis (GSEA) revealed their molecular mechanisms. The diagnostic biomarkers were selected via receiver operating characteristic (ROC) analysis. Moreover, an analysis of immune elements i

SUBMITTER: You H 

PROVIDER: S-EPMC11079106 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature