The Intellectual Disability Risk Gene <i>Kdm5b</i> Regulates Long-Term Memory Consolidation in the Hippocampus.

ABSTRACT: The histone lysine demethylase KDM5B is implicated in recessive intellectual disability disorders, and heterozygous, protein-truncating variants in KDM5B are associated with reduced cognitive function in the population. The KDM5 family of lysine demethylases has developmental and homeostatic functions in the brain, some of which appear to be independent of lysine demethylase activity. To determine the functions of KDM5B in hippocampus-dependent learning and memory, we first studied male and female mice homozygous for a Kdm5b ^{Δ ARID} allele that lacks demethylase activity. Kdm5b ^{Δ ARID/ Δ ARID} mice exhibited hyperactivity and long-term memory deficits in hippocampus-dependent learning tasks. The expression o

SUBMITTER: Perez-Sisques L 

PROVIDER: S-EPMC11079963 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature