Genetically predicted gut microbiota mediate the association between plasma lipidomics and primary sclerosing cholangitis.

ABSTRACT:

Background

Primary sclerosing cholangitis (PSC) is a complex disease with pathogenic mechanisms that remain to be elucidated. Previous observational studies with small sample sizes have reported associations between PSC, dyslipidemia, and gut microbiota dysbiosis. However, the causality of these associations is uncertain, and there has been no systematic analysis to date.

Methods

The datasets comprise data on PSC, 179 lipid species, and 412 gut microbiota species. PSC data (n = 14,890) were sourced from the International PSC Study Group, while the dataset pertaining to plasma lipidomics originated from a study involving 7174 Finnish individuals. Data on gut microbiota species were derived from the Dutch Microbiome Project study, which conducted a genome-wide association stud

SUBMITTER: Zhou J 

PROVIDER: S-EPMC11080140 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature