Characterizing genetic variation on the Z chromosome in Schistosoma japonicum reveals host-parasite co-evolution.

ABSTRACT:

Background

Schistosomiasis is a neglected tropical disease that afflicts millions of people worldwide; it is caused by Schistosoma, the only dioecious flukes with ZW systems. Schistosoma japonicum is endemic to Asia; the Z chromosome of S. japonicum comprises one-quarter of the entire genome. Detection of positive selection using resequencing data to understand adaptive evolution has been applied to a variety of pathogens, including S. japonicum. However, the contribution of the Z chromosome to evolution and adaptation is often neglected.

Methods

We obtained 1,077,526 high-quality SNPs on the Z chromosome in 72 S. japonicum using re-sequencing data publicly. To examine the faster Z effect, we compared the sequence divergence of S. japonicum with two closely related species,

SUBMITTER: Zhou A 

PROVIDER: S-EPMC11080191 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature