Comprehensive dry eye therapy: overcoming ocular surface barrier and combating inflammation, oxidation, and mitochondrial damage.

ABSTRACT:

Background

Dry Eye Disease (DED) is a prevalent multifactorial ocular disease characterized by a vicious cycle of inflammation, oxidative stress, and mitochondrial dysfunction on the ocular surface, all of which lead to DED deterioration and impair the patients' quality of life and social functioning. Currently, anti-inflammatory drugs have shown promising efficacy in treating DED; however, such drugs are associated with side effects. The bioavailability of ocular drugs is less than 5% owing to factors such as rapid tear turnover and the presence of the corneal barrier. This calls for investigations to overcome these challenges associated with ocular drug administration.

Results

A novel hierarchical action liposome nanosystem (PHP-DPS@INS) was developed in this study. In ter

SUBMITTER: Xia Y 

PROVIDER: S-EPMC11080212 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature