Causal relationship between serum metabolites and juvenile idiopathic arthritis: a mendelian randomization study.

ABSTRACT:

Background

Juvenile Idiopathic Arthritis (JIA) is a condition that occurs when individuals under the age of 16 develop arthritis that lasts for more than six weeks, and the cause is unknown. The development of JIA may be linked to serum metabolites. Nevertheless, the association between JIA pathogenesis and serum metabolites is unclear, and there are discrepancies in the findings across studies.

Methods

In this research, the association between JIA in humans and 486 serum metabolites was assessed using genetic variation data and genome-wide association study. The identification of causal relationships was accomplished through the application of univariate Mendelian randomization (MR) analysis. Various statistical methods, including inverse variance weighted and MR-Egger, wer

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11080266 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature