Prescription Opioids and Brain Structure in Community-Dwelling Older Adults.

ABSTRACT:

Objective

To evaluate the associations between prescription opioid exposures in community-dwelling older adults and gray and white matter structure by magnetic resonance imaging.

Methods

Secondary analysis was conducted of a prospective, longitudinal population-based cohort study employing cross-sectional imaging of older adult (≥65 years) enrollees between November 1, 2004, and December 31, 2017. Gray matter outcomes included cortical thickness in 41 structures and subcortical volumes in 6 structures. White matter outcomes included fractional anisotropy in 40 tracts and global white matter hyperintensity volumes. The primary exposure was prescription opioid availability expressed as the per-year rate of opioid days preceding magnetic resonance imaging, with a secondary expo

SUBMITTER: Warner NS 

PROVIDER: S-EPMC11081533 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature