Cardiac GR Mediates the Diurnal Rhythm in Ventricular Arrhythmia Susceptibility.

ABSTRACT:

Background

Ventricular arrhythmias (VAs) demonstrate a prominent day-night rhythm, commonly presenting in the morning. Transcriptional rhythms in cardiac ion channels accompany this phenomenon, but their role in the morning vulnerability to VAs and the underlying mechanisms are not understood. We investigated the recruitment of transcription factors that underpins transcriptional rhythms in ion channels and assessed whether this mechanism was pertinent to the heart's intrinsic diurnal susceptibility to VA.

Methods and results

Assay for transposase-accessible chromatin with sequencing performed in mouse ventricular myocyte nuclei at the beginning of the animals' inactive (ZT0) and active (ZT12) periods revealed differentially accessible chromatin sites annotating to rhythmica

SUBMITTER: Tikhomirov R 

PROVIDER: S-EPMC11081863 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature