SOCS3 regulates pathological retinal angiogenesis through modulating SPP1 expression in microglia and macrophages.

ABSTRACT: Pathological ocular angiogenesis has long been associated with myeloid cell activation. However, the precise cellular and molecular mechanisms governing the intricate crosstalk between the immune system and vascular changes during ocular neovascularization formation remain elusive. In this study, we demonstrated that the absence of the suppressor of cytokine signaling 3 (SOCS3) in myeloid cells led to a substantial accumulation of microglia and macrophage subsets during the neovascularization process. Our single-cell RNA sequencing data analysis revealed a remarkable increase in the expression of the secreted phosphoprotein 1 (Spp1) gene within these microglia and macrophages, identifying subsets of Spp1-expressing microglia and macrophages during neovascularization formation in angiogenes

SUBMITTER: Wang T 

PROVIDER: S-EPMC11081920 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature