Effects of lifestyle and associated diseases on serum CC16 suggest complex interactions among metabolism, heart and lungs.

ABSTRACT:

Introduction

Clara cell 16-kDa protein (CC16) is an anti-inflammatory, immunomodulatory secreted pulmonary protein with reduced serum concentrations in obesity according to recent data.

Objective

Studies focused solely on bodyweight, which does not properly reflect obesity-associated implications of the metabolic and reno-cardio-vascular system. The purpose of this study was therefore to examine CC16 in a broad physiological context considering cardio-metabolic comorbidities of primary pulmonary diseases.

Methods

CC16 was quantified in serum samples in a subset of the FoCus (N = 497) and two weight loss intervention cohorts (N = 99) using ELISA. Correlation and general linear regression analyses were applied to assess CC16 effects of lifestyle, gut microbiota, disease

SUBMITTER: Rohmann N 

PROVIDER: S-EPMC11081936 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature