Exploiting in silico modelling to enhance translation of liver cell therapies from bench to bedside.

ABSTRACT: Cell therapies are emerging as promising treatments for a range of liver diseases but translational bottlenecks still remain including: securing and assessing the safe and effective delivery of cells to the disease site; ensuring successful cell engraftment and function; and preventing immunogenic responses. Here we highlight three therapies, each utilising a different cell type, at different stages in their clinical translation journey: transplantation of multipotent mesenchymal stromal/signalling cells, hepatocytes and macrophages. To overcome bottlenecks impeding clinical progression, we advocate for wider use of mechanistic in silico modelling approaches. We discuss how in silico approaches, alongside complementary experimental approaches, can enhance our understanding of the mechanism

SUBMITTER: Ashmore-Harris C 

PROVIDER: S-EPMC11081951 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature