Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS.

ABSTRACT: Aging affects all cell types in the CNS and plays an important role in CNS diseases. However, the underlying molecular mechanisms driving these age-associated changes and their contribution to diseases are only poorly understood. The white matter in the aging brain as well as in diseases, such as Multiple sclerosis is characterized by subtle abnormalities in myelin sheaths and paranodes, suggesting that oligodendrocytes, the myelin-maintaining cells of the CNS, lose the capacity to preserve a proper myelin structure and potentially function in age and certain diseases. Here, we made use of directly converted oligodendrocytes (dchiOL) from young, adult and old human donors to study age-associated changes. dchiOL from all three age groups differentiated in an comparable manner into O4 + imma

SUBMITTER: Windener F 

PROVIDER: S-EPMC11082024 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature