Prognostic implications of STK11 with different mutation status and its relationship with tumor-infiltrating immune cells in non-small cell lung cancer.

ABSTRACT:

Background

Mutations in STK11 (STK11^Mut) gene may present a negative impact on survival in Non-small Cell Lung Cancer (NSCLC) patients, however, its relationship with immune related genes remains unclear. This study is to unveil whether overexpressed- and mutated-STK11 impact survival in NSCLC and to explore whether immune related genes (IRGs) are involved in STK11 mutations.

Methods

188 NSCLC patients with intact formalin-fixed paraffin-embedded (FFPE) tissue available for detecting STK11 protein expression were included in the analysis. After immunohistochemical detection of STK11 protein, patients were divided into high STK11 expression group (STK11^High) and low STK11 expression group (STK11^Low), and then Kaplan-Meier survival analysis and

SUBMITTER: Zheng J 

PROVIDER: S-EPMC11082287 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature