Gut microbiota composition in travellers is associated with faecal lipocalin-2, a mediator of gut inflammation.

ABSTRACT:

Introduction

We examined the gut microbiota of travellers returning from tropical areas with and without traveller's diarrhoea (TD) and its association with faecal lipocalin-2 (LCN2) levels.

Methods

Participants were recruited at the Hospital Clinic of Barcelona, Spain, and a single stool sample was collected from each individual to perform the diagnostic of the etiological agent causing gastrointestinal symptoms as well as to measure levels of faecal LCN2 as a biomarker of gut inflammation. We also characterised the composition of the gut microbiota by sequencing the region V3-V4 from the 16S rRNA gene, and assessed its relation with the clinical presentation of TD and LCN2 levels using a combination of conventional statistical tests and unsupervised machine learning approa

SUBMITTER: Gandasegui J 

PROVIDER: S-EPMC11082338 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature