DNA methylation regulator-based molecular subtyping and tumor microenvironment characterization in hepatocellular carcinoma.

ABSTRACT:

Backgroud

Although recent studies have reported the regulation of the immune response in hepatocellular carcinoma (HCC) through DNA methylation, the comprehensive impact methylation modifications on tumor microenvironment characteristics and immunotherapy efficacy has not been fully elucidated.

Methods

In this research, we conducted a comprehensive assessment of the patterns of DNA methylation regulators and the profiles of the tumor microenvironment (TME) in HCC, focusing on 21 specific DNA methylation regulators. We subsequently developed a unique scoring system, a DNA methylation score (DMscore), to assess the individual DNA methylation modifications among the three distinct methylation patterns for differentially expressed genes (DEGs).

Results

Three distinct meth

SUBMITTER: Zhao J 

PROVIDER: S-EPMC11082416 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature