Dose-Adjusted EPOCH Plus Inotuzumab Ozogamicin in Adults With Relapsed or Refractory B-Cell ALL: A Phase 1 Dose-Escalation Trial.

ABSTRACT:

Importance

Options for adults with relapsed or refractory B-cell acute lymphoblastic leukemia or lymphoma (B-ALL) are limited, and new approaches are needed. Inotuzumab ozogamicin (InO) has been combined with low-intensity chemotherapy, with modest improvements over historical controls, and dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (DA-EPOCH) treatment is safe and active for newly diagnosed ALL.

Objective

To assess the safety and clinical activity of DA-EPOCH and InO in adults with relapsed or refractory B-ALL.

Design, setting, and participants

This single-center, single-arm, nonrandomized, phase 1 dose-escalation trial included adults with relapsed or refractory CD22+ B-ALL and was conducted between September 2019 and Novembe

SUBMITTER: Kopmar NE 

PROVIDER: S-EPMC11082746 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature