Pegcetacoplan Treatment and Consensus Features of Geographic Atrophy Over 24 Months.

ABSTRACT:

Importance

Despite widespread availability and consensus on its advantages for detailed imaging of geographic atrophy (GA), spectral-domain optical coherence tomography (SD-OCT) might benefit from automated quantitative OCT analyses in GA diagnosis, monitoring, and reporting of its landmark clinical trials.

Objective

To analyze the association between pegcetacoplan and consensus GA SD-OCT end points.

Design, setting, and participants

This was a post hoc analysis of 11 614 SD-OCT volumes from 936 of the 1258 participants in 2 parallel phase 3 studies, the Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (OAKS) and Study to Compare the Effica

SUBMITTER: Fu DJ 

PROVIDER: S-EPMC11082756 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature