Sulfide quinone oxidoreductase contributes to voltage sensing of the mitochondrial permeability transition pore.

ABSTRACT: Pathological opening of the mitochondrial permeability transition pore (mPTP) is implicated in the pathogenesis of many disease processes such as myocardial ischemia, traumatic brain injury, Alzheimer's disease, and diabetes. While we have gained insight into mPTP biology over the last several decades, the lack of translation of this knowledge into successful clinical therapies underscores the need for continued investigation and use of different approaches to identify novel regulators of the mPTP with the hope of elucidating new therapeutic targets. Although the mPTP is known to be a voltage-gated channel, the identity of its voltage sensor remains unknown. Here we found decreased gating potential of the mPTP and increased expression and activity of sulfide quinone oxidoreductase (SQOR) i

SUBMITTER: Griffiths KK 

PROVIDER: S-EPMC11082757 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature