Anti-Obesity Therapeutic Targets Studied In Silico and In Vivo: A Systematic Review.

ABSTRACT: In the age of information technology and the additional computational search tools and software available, this systematic review aimed to identify potential therapeutic targets for obesity, evaluated in silico and subsequently validated in vivo. The systematic review was initially guided by the research question "What therapeutic targets have been used in in silico analysis for the treatment of obesity?" and structured based on the acronym PECo (P, problem; E, exposure; Co, context). The systematic review protocol was formulated and registered in PROSPERO (CRD42022353808) in accordance with the Preferred Reporting Items Checklist for Systematic Review and Meta-Analysis Protocols (PRISMA-P), and the PRISMA was followed for the systematic review. The studies were selected according to the e

SUBMITTER: de Medeiros WF 

PROVIDER: S-EPMC11083175 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature