Functional characterization of helminth-associated Clostridiales reveals covariates of Treg differentiation.

ABSTRACT:

Background

Parasitic helminths influence the composition of the gut microbiome. However, the microbiomes of individuals living in helminth-endemic regions are understudied. The Orang Asli, an indigenous population in Malaysia with high burdens of the helminth Trichuris trichiura, display microbiotas enriched in Clostridiales, an order of spore-forming obligate anaerobes with immunogenic properties. We previously isolated novel Clostridiales that were enriched in these individuals and found that a subset promoted the Trichuris life cycle. In this study, we aimed to further characterize the functional properties of these bacteria.

Results

Clostridiales isolates were profiled for their ability to perform 57 enzymatic reactions and produce short-chain fatty acids (SCFAs) and hyd

SUBMITTER: Sargsian S 

PROVIDER: S-EPMC11084060 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature