Insertion of short L1 sequences generates inter-strain histone acetylation differences in the mouse.

ABSTRACT:

Background

Gene expression divergence between populations and between individuals can emerge from genetic variations within the genes and/or in the cis regulatory elements. Since epigenetic modifications regulate gene expression, it is conceivable that epigenetic variations in cis regulatory elements can also be a source of gene expression divergence.

Results

In this study, we compared histone acetylation (namely, H3K9ac) profiles in two mouse strains of different subspecies origin, C57BL/6 J (B6) and MSM/Ms (MSM), as well as their F1 hybrids. This identified 319 regions of strain-specific acetylation, about half of which were observed between the alleles of F1 hybrids. While the allele-specific presence of the interferon regulatory factor 3 (IRF3) binding sequence was assoc

SUBMITTER: Boyboy BAG 

PROVIDER: S-EPMC11084082 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature