Evaluation of serological assays for the diagnosis of childhood tuberculosis disease: a study protocol.

ABSTRACT:

Background

Tuberculosis (TB) poses a major public health challenge, particularly in children. A substantial proportion of children with TB disease remain undetected and unconfirmed. Therefore, there is an urgent need for a highly sensitive point-of-care test. This study aims to assess the performance of serological assays based on various antigen targets and antibody properties in distinguishing children (0-18 years) with TB disease (1) from healthy TB-exposed children, (2) children with non-TB lower respiratory tract infections, and (3) from children with TB infection.

Methods

The study will use biobanked plasma samples collected from three prospective multicentric diagnostic observational studies: the Childhood TB in Switzerland (CITRUS) study, the Pediatric TB Research Ne

SUBMITTER: Neudecker D 

PROVIDER: S-EPMC11084122 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature