Host RNA Expression Signatures in Young Infants with Urinary Tract Infection: A Prospective Study.

ABSTRACT: Early diagnosis of infections in young infants remains a clinical challenge. Young infants are particularly vulnerable to infection, and it is often difficult to clinically distinguish between bacterial and viral infections. Urinary tract infection (UTI) is the most common bacterial infection in young infants, and the incidence of associated bacteremia has decreased in the recent decades. Host RNA expression signatures have shown great promise for distinguishing bacterial from viral infections in young infants. This prospective study included 121 young infants admitted to four pediatric emergency care departments in the capital region of Denmark due to symptoms of infection. We collected whole blood samples and performed differential gene expression analysis. Further, we tested the classif

SUBMITTER: Dungu KHS 

PROVIDER: S-EPMC11084417 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature