Metabolome-associated psychological comorbidities improvement in irritable bowel syndrome patients receiving a probiotic.

ABSTRACT: Our recent randomized, placebo-controlled study in Irritable Bowel Syndrome (IBS) patients with diarrhea or alternating bowel habits showed that the probiotic Bifidobacterium longum (BL) NCC3001 improves depression scores and decreases brain emotional reactivity. However, the involved metabolic pathways remain unclear. This analysis aimed to investigate the biochemical pathways underlying the beneficial effects of BL NCC3001 using metabolomic profiling. Patients received probiotic (1x 10¹⁰CFU, n=16) or placebo (n=19) daily for 6 weeks. Anxiety and depression were measured using the Hospital Anxiety and Depression Scale. Brain activity in response to negative emotional stimuli was assessed by functional Magnetic Resonance Imaging. Probiotic fecal abundance was quantified b

SUBMITTER: Martin FP 

PROVIDER: S-EPMC11085950 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature