Commensal microbiota-derived metabolite agmatine triggers inflammation to promote colorectal tumorigenesis.

ABSTRACT: Colorectal cancer (CRC), a malignant tumor worldwide, is associated with gut microbiota. The influence of gut microbe-derived metabolites on CRC has attracted a lot of attention. However, the role of immunity mediated by commensal microbiota-derived metabolites in tumorigenesis of CRC is not intensively explored. Here we monitored the gut microbial dysbiosis in CRC mouse model (Apc^Min/+ model) without dietary and pharmacological intervention, followed by characterized of metabolites enriched in CRC model mice. Profound changes of gut microbiome (bacteriome) were observed during intestinal disorders. Metabolomic profiling indicated that agmatine, derived from the gut bacteria i.e. Blautia, Odoribacter, Alistipes and Paraprevotella, could interact with

SUBMITTER: Lu Y 

PROVIDER: S-EPMC11086030 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature