Shared genetic architecture highlights the bidirectional association between major depressive disorder and fracture risk.

ABSTRACT:

Background

There is limited evidence suggesting that osteoporosis might exacerbate depressive symptoms, while more studies demonstrate that depression negatively affects bone density and increases fracture risk.

Aims

To explore the relationship between major depressive disorder (MDD) and fracture risk.

Methods

We conducted a nested case-control analysis (32 670 patients with fracture and 397 017 individuals without fracture) and a matched cohort analysis (16 496 patients with MDD and 435 492 individuals without MDD) in the same prospective UK Biobank data set. Further, we investigated the shared genetic architecture between MDD and fracture with linkage disequilibrium score regression and the MiXeR statistical tools. We used the conditional/conjunctional false discove

SUBMITTER: Zhao P 

PROVIDER: S-EPMC11086190 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature