SUPRAMAX-study: supramaximal resection versus maximal resection for glioblastoma patients: study protocol for an international multicentre prospective cohort study (ENCRAM 2201).

ABSTRACT:

Introduction

A greater extent of resection of the contrast-enhancing (CE) tumour part has been associated with improved outcomes in glioblastoma. Recent results suggest that resection of the non-contrast-enhancing (NCE) part might yield even better survival outcomes (supramaximal resection, SMR). Therefore, this study evaluates the efficacy and safety of SMR with and without mapping techniques in high-grade glioma (HGG) patients in terms of survival, functional, neurological, cognitive and quality of life outcomes. Furthermore, it evaluates which patients benefit the most from SMR, and how they could be identified preoperatively.

Methods and analysis

This study is an international, multicentre, prospective, two-arm cohort study of observational nature. Consecutive glioblasto

SUBMITTER: Gerritsen JKW 

PROVIDER: S-EPMC11086386 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature