Anti-TNF (adalimumab) injection for the treatment of pain-predominant early-stage frozen shoulder: the Anti-Freaze-Feasibility randomised controlled trial.

ABSTRACT:

Objective

The Anti-Freaze-F (AFF) trial assessed the feasibility of conducting a definitive trial to determine whether intra-articular injection of adalimumab can reduce pain and improve function in people with pain-predominant early-stage frozen shoulder.

Design

Multicentre, randomised feasibility trial, with embedded qualitative study.

Setting

Four UK National Health Service (NHS) musculoskeletal and related physiotherapy services.

Participants

Adults ≥18 years with new episode of shoulder pain attributable to early-stage frozen shoulder.

Interventions

Participants were randomised (centralised computer generated 1:1 allocation) to either ultrasound-guided intra-articular injection of: (1) adalimumab (160 mg) or (2) placebo (saline (0.9% sodium chloride

SUBMITTER: Hopewell S 

PROVIDER: S-EPMC11086567 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature