Individualized Dose-Response to Statins Associated with Cardiovascular Disease Outcomes.

ABSTRACT:

Background

Statins reduce low-density lipoprotein cholesterol (LDL-C) and are efficacious in the prevention of atherosclerotic cardiovascular disease (ASCVD). Dose-response to statins varies among patients and can be modeled using three distinct pharmacological properties: (1) E₀ (baseline LDL-C), (2) ED₅₀ (potency: median dose achieving 50% reduction in LDL-C); and (3) E_max (efficacy: maximum LDL-C reduction). However, individualized dose-response and its association with ASCVD events remains unknown.

Objective

We analyze the relationship between ED₅₀ and E_max with real-world cardiovascular disease outcomes.

Method

We leveraged de-identified electronic health record data to identify individuals exposed to multipl

SUBMITTER: Aggarwal SK 

PROVIDER: S-EPMC11086740 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature