Change in Cone Structure Over 24 Months in USH2A-Related Retinal Degeneration.

ABSTRACT:

Purpose

To describe cone structure changes using adaptive optics scanning laser ophthalmoscopy (AOSLO) in the Rate of Progression of USH2A-related Retinal Degeneration (RUSH2A) study.

Design

Multicenter, longitudinal natural history study.

Methods

AOSLO images were acquired at 4 centers, twice at baseline and annually for 24 months in this natural history study. For each eye, at least 10 regions of interest (ROIs) with ≥50 contiguous cones were analyzed by masked, independent graders. Cone spacing Z-scores, standard deviations from the normal mean at the measured location, were compared between graders and tests at baseline. The association of cone spacing with clinical characteristics was assessed using linear mixed effects regression models weighted by image quality

SUBMITTER: Duncan JL 

PROVIDER: S-EPMC11087021 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature