Knockdown of PHOX2B in the retrotrapezoid nucleus reduces the central CO₂ chemoreflex in rats.

ABSTRACT: PHOX2B is a transcription factor essential for the development of different classes of neurons in the central and peripheral nervous system. Heterozygous mutations in the PHOX2B coding region are responsible for the occurrence of Congenital Central Hypoventilation Syndrome (CCHS), a rare neurological disorder characterised by inadequate chemosensitivity and life-threatening sleep-related hypoventilation. Animal studies suggest that chemoreflex defects are caused in part by the improper development or function of PHOX2B expressing neurons in the retrotrapezoid nucleus (RTN), a central hub for CO₂ chemosensitivity. Although the function of PHOX2B in rodents during development is well established, its role in the adult respiratory network remains unknown. In this study, we investig

SUBMITTER: Cardani S 

PROVIDER: S-EPMC11087052 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature