Age and aging process alter the gut microbes.

ABSTRACT:

Background

Gut microbes and age are both factors that influence the development of disease. The community structure of gut microbes is affected by age.

Objective

To plot time-dependent gut microbe profiles in individuals over 45 years old and explore the correlation between age and gut microbes.

Methods

Fecal samples were collected from 510 healthy individuals over 45 years old. Shannon index, Simpson index, Ace index, etc. were used to analyze the diversity of gut microbes. The beta diversity analysis, including non-metric multidimensional scaling (NMDS), was used to analyze community distribution. Linear discriminant analysis (LDA) and random forest (RF) algorithm were used to analyze the differences of gut microbes. Trend analysis was used to plot the abundances of

SUBMITTER: Zhanbo Q 

PROVIDER: S-EPMC11087091 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature