Characterisation of novel influenza-derived HLA-B*18:01-restricted epitopes.

ABSTRACT:

Objectives

Seasonal influenza viruses cause roughly 650 000 deaths annually despite available vaccines. CD8⁺ T cells typically recognise influenza-derived peptides from internal structural and non-structural influenza proteins and are an attractive avenue for future vaccine design as they could reduce the severity of disease following infection with diverse influenza strains. CD8⁺ T cells recognise peptides presented by the highly polymorphic Human Leukocyte Antigens class I molecules (HLA-I). Each HLA-I variant has distinct peptide binding preferences, representing a significant obstacle for designing vaccines that elicit CD8⁺ T cell responses across broad populations. Consequently, the rational design of a CD8⁺ T cell-mediated vaccine w

SUBMITTER: Leong SL 

PROVIDER: S-EPMC11087170 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature