Proteomic analysis reveals potential therapeutic targets for childhood asthma through Mendelian randomization.

ABSTRACT:

Background

Asthma is the most common chronic disease among children and poses a significant threat to their health. This study aims to assess the relationship between various plasma proteins and childhood asthma, thereby identifying potential therapeutic targets.

Methods

Based on publicly available genome-wide association study summary statistics, we employed a two-sample Mendelian randomization (MR) approach to elucidate the causal relationship between plasma proteins and asthma. Mediation analysis was then conducted to evaluate the indirect influence of plasma proteins on childhood asthma mediated through risk factors. Comprehensive analysis was also conducted to explore the association between plasma proteins and various phenotypes using the UK Biobank dataset.

Results

SUBMITTER: Wu YQ 

PROVIDER: S-EPMC11087394 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature