New amide and diterpene alkaloids with anticholinesterase activity from Delphinium cyphoplectrum roots.

ABSTRACT:

Background

The cholinergic hypothesis posits a robust correlation between the onset of Alzheimer's disease and a pronounced deficit in acetylcholine, a pivotal neurotransmitter crucial for the central cholinergic nervous system's function, pivotal for memory and learning. Diterpene alkaloids exhibit intricate and distinctive chemical structures that facilitate their passage through the blood-brain barrier. Moreover, their potent pharmacological attributes render them promising candidates for addressing central nervous system disorders.

Objectives

This investigation aims to scrutinize the alkaloidal composition of Delphinium cyphoplectrum (Ranunculaceae) roots, further exploring their anticholinesterase inhibitory activity and mode of inhibition.

Method

Innovative chro

SUBMITTER: Salehi A 

PROVIDER: S-EPMC11087438 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature